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HUMAN RELAXIN RECEPTOR 1 (aa 609-624)
ANTIBODY, POLYCLONAL
 
Catalog no.: A 9227.1 / A 9227.2
 
Immunogen: Synthetic human Relaxin Receptor 1 (aa 609-624) (SAITATEIRNQVKKEM) KLH-conjugated

Synonyms: Relaxin family peptide receptor 1 (RXFP1), Leucine-rich repeat-containing G-protein coupled receptor 7 (LGR7)
 
Swiss-Prot No: Q9HBX9
 
Gene Information: Gene Name: RXFP1
GenelD: 59350
 
Host: Rabbit
 
Matrix: Serum
 
Specificity: Human, monkey (macaque, marmoset), porcine, rat, and mouse Relaxin Receptor 1
There was no cross-reactivity obtained with human Relaxin Receptor 2 (RXFP2, LGR8).
 
Contents: 20 μl / 100 μl (lyophilized)
Resuspend in 20 μl / 100 μl aqua bidest.
 
Known applications: immunocytochemistry (1:4000)1, immunohistochemistry (paraffin sections, 1:2000 - 1:5000)1, 2, 3, 4
This antibody has not been tested for use in all applications. This does not necessarily exclude its use in non-tested procedures. The stated dilutions are recommendations only. End users should determine optimal dilutions in their system using appropriate negative/positive controls.
 
Store at: 2-8 °C (lyophilized); - 20 °C (dissolved)
Repeated thawing and freezing must be avoided
 
References:
1. Ivlll R, Balvers M, Pohnke Y, Telgmann R, Bartsch O, Milde-Langosch K, Bamberger AM, Einspanier A (2003). Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates. Reprod Biol Endocrinol 1:114.
2. Yan W, Wiley AA, Bathgate RAD, Frankshun AL, Lasano S, Crean BD, Steinetz BG, Bagnell CA, Bartol FF (2006). Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling. Endocrinology 147(9): 4303-4310.
3. Squecco R, Garella R, ldrizaj E, Nistri S, Francini F & Baccari MC (2015). Relaxin affects smooth muscle biophysical properties and mechanical activity of the female mouse colon. Endocrinology 2015 Dec;156(12):4398-410.
4. Kaftanovskaya EM, Soula M, Myhr C, Ho BA, Moore SN, Yoo C, Cervantes B, How J, Marugan J, Agoulnik IU, Agoulnik AI (2017). Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML 290. J Endocr Soc. 2017 Jun;1(6):712-725.
 
For research use only

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