Mice from which antibody is isolated show clinical evidence of epidermolysis bullosa acquisita (EBA)
This antibody has not been tested for use in all applications. This does not necessarily exclude its use in non-tested procedures. The stated dilutions are recommendations only. End users should determine optimal dilutions/concentrations in their system using appropriate negative/ positive controls.
Store at: 2-8 °C (lyophilized); - 20 °C (dissolved)
Repeated thawing and freezing must be avoided
References:
1. Sitaru C, Mihai S, Otto C, Chiriac MT, Hausser I, Dotterweich B, Saito H, Rose C, Ishiko A, Zllikens D (2005). Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen. J Clin Invest 115(4): 870-878.
2. Sitaru C, Chiriac MT, Mihai S, Buning J, Gebert A, Ishiko A, Zllikens D (2006). Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177(5): 3461-3468.
For research use only
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